Preston upset Fulham in Carabao-Cup record shootout - ESPN

Championship side Preston North End secured the biggest shock of the Carabao Cup third round on Tuesday, beating Premier League Fulham 16-15 in the longest penalty shootout in the competition's history.

The game ended 1-1 at full time with Ryan Ledson putting Preston ahead in the 35th and Reiss Nelson equalising for Fulham in the 61st.

What followed was the longest shootout in the 64-year history of the League Cup, with Preston eventually triumphing after 34 spot kicks.

After 32 penalties were successfully converted, Fulham's Timothy Castagne missed the target and Ledson made no mistake to fire Preston into the fourth round.

Elsewhere on Tuesday, Everton's troubled campaign went from bad to worse after they were eliminated by second-to-last Southampton -- losing 6-5 on penalties.

Bottom of the Premier League and without a point, Everton had taken the lead through Abdoulaye Doucouré in the 20th at Goodison Park, but Taylor Harwood-Bellis evened the game in the 32nd.

Southampton goalkeeper Alex McCarthy saved Ashley Young's penalty in sudden death to seal Everton's fate.

Eberechi Eze struck the winner as Crystal Palace beat second-tier Queens Park Rangers 2-1 and Brentford survived an early scare against third-tier Leyton Orient to win 3-1.

Brandon Cooper fired Orient ahead in the 11th, but Fábio Carvalho, Mikkel Damsgaard and Christian Norgaard eased Brentford to victory.

Stoke overcame Fleetwood 2-1 on penalties after a 1-1 draw, Sheffield Wednesday beat Blackpool 1-0 and Man United dismissed Barnsley 7-0.

Information from The Associated Press contributed to this report.